If you do not order the Lab Result Only, then in ADDITION to your lab report we provide the following options which are INCLUDED in the package prices:

A) Follow up personalised written report produced by our clinical team highlighting dietary and lifestyle advice plus links to supplement protocols, specific doses and any further testing requirements included. We use the patient information you provide us at checkout along with your results to compile personalised action points for you.

OR

B) Follow up 30-minute video call to discuss your results and answer any questions you have. Once the lab has completed your results you will be sent these via email with a link to book a time and day online. You will also then be given the option to upgrade your 30-minute call to a 45-minute call for an additional £30 if you wish. During the call your practitioner will explain the results in more detail and what they mean for you. After your call you are sent a personalised list of supplements & the dose your practitioner advises with links to purchase from our supplements store. This is for your convenience. You are of course welcome to purchase supplements elsewhere. You will also be provided with a list of follow up tests should this be required plus a copy of your recorded zoom call which you can download and keep.

OR

C) Both Zoom call and written report with personalised next steps (Zoom call is first and written report follows).

This blood test will not give you information on your genetic mutations. It will give you information on your current levels of certain markers within the methylation cycle so you get a ‘live’ picture of nutrient requirements.

• Autism
• Birth Defects
• Cancer
• Cardiovascular Disease
• Congenital Heart Disease
• Detoxification Impairment
• General Health and Longevity
• Genetic Disorders
• Immune Dysfunction
• Neurodegenerative Diseases
• Nutritional Deficiencies
• Psychiatric Disorders

Your kit is posted to you from the UK within 24–48 hours of ordering so you should receive your test kit within a few days via DHL. You can then arrange for DHL to collect your sample using the freepost returns.

Instructions for using your own phlebotomist are:

Freeze the gel ice brick the night before your test and take the kit box and instructions to your chosen phlebotomist and request a centrifuged sample. Once completed, add your personal details and time of test on the vial as per the instruction sheet. Place the vial in the zip lock bag with the frozen ice brick and upon returning home, pop your bloods and the gel pack back in the freezer before arranging your returns. Ensure your frozen sample is collected by DHL within 48 hours.

Book your blood to be drawn and collected Monday to Thursday only, ensuring the next day is not a bank holiday or weekend in the UK.

This test requires a full blood sample which is NOT included in your test cost. If you require assistance finding a phlebotomist in your area that can centrifuge a sample - please use this link once you have purchased - https://finder.bloodsandbeyond.co.uk/finder

• Fast for 12 hours before your blood test
• Do not stop any medications
• For 48 hours prior to the collection, discontinue taking dietary supplements containing methionine, cysteine, SAMe, and vitamins containing folate unless otherwise directed by your physician
• Please only send samples back Mon–Thurs

This test measures seven analytes that map the core of the methylation and transsulfuration pathways:

• Homocysteine — the central intermediate; elevated levels are an independent risk factor for cardiovascular disease and indicate impaired recycling through methylation or transsulfuration
• Methionine — the essential amino acid that feeds into the methylation cycle
• SAM (S-adenosylmethionine) — the body's primary methyl donor, required for DNA repair, neurotransmitter synthesis, and detoxification
• SAH (S-adenosylhomocysteine) — the byproduct of methylation reactions; elevated SAH inhibits further methylation and may be an even stronger predictor of cardiovascular risk than homocysteine alone
• Methylation index (SAM:SAH ratio) — a sensitive indicator of overall methylation capacity; a low ratio signals under-methylation
• Cystathionine — an intermediate in the transsulfuration pathway that converts homocysteine towards cysteine and glutathione production
• Cysteine — the rate-limiting amino acid for glutathione synthesis, which is essential for detoxification, immune function, and antioxidant defence
• Adenosine — must be efficiently cleared to prevent SAH accumulation and methylation inhibition

Together, these markers reveal whether your body is methylating efficiently, recycling homocysteine properly, and producing adequate glutathione — information that a standalone homocysteine reading cannot provide.

The Homocysteine Plasma Profile is suitable for anyone aged 18 and over who wants to assess their methylation and cardiovascular risk status. It is particularly relevant if you:

• Have a personal or family history of cardiovascular disease, stroke, or blood clots
• Carry known MTHFR gene variants and want to see how these are expressing in real-time biochemistry
• Experience symptoms associated with poor methylation — chronic fatigue, brain fog, depression, anxiety, or neurological symptoms
• Have B6, B12, or folate deficiency that has not responded adequately to supplementation
• Are concerned about cognitive decline, memory loss, or a family history of neurodegenerative disease
• Have impaired detoxification or suspect low glutathione levels are contributing to chemical sensitivity, chronic inflammation, or immune dysfunction
• Have experienced recurrent miscarriage or pregnancy complications where homocysteine may be a contributing factor

The analytes in this profile — particularly SAM and SAH — are unstable in whole blood and begin to degrade rapidly after the sample is drawn. Centrifuging separates the plasma from the blood cells and allows the sample to be frozen immediately, preserving accurate levels for analysis. This is a more demanding sample handling requirement than a standard blood test, which is why a qualified phlebotomist with access to a centrifuge is needed. The phlebotomy visit is not included in the test cost. Once you have purchased the kit, you can use the Bloods & Beyond finder linked on the product page to locate a phlebotomist in your area who offers centrifuged samples. Your blood must be drawn Monday to Thursday, ensuring the following day is not a bank holiday or weekend, and the frozen sample must be collected by DHL within 48 hours.