MTHFR Guide

MTHFR Guide

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Understanding the MTHFR Gene: Functions, Variants, and Implications

The MTHFR (Methylenetetrahydrofolate Reductase) gene is a key player in a critical metabolic process known as methylation, which is essential for DNA synthesis, repair, and overall cellular function. The enzyme produced by the MTHFR gene converts 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, the active form of folate. This active folate is crucial for converting homocysteine into methionine, an amino acid necessary for many biological functions, including the synthesis of proteins and neurotransmitters.

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Could It Be MCAS? Understanding Mast Cell Activation and How to Start Untangling “Mystery Symptoms”

Could It Be MCAS? Understanding Mast Cell Activation and How to Start Untangling “Mystery Symptoms”

Have you been living with a cluster of unexplained symptoms such as hives or rashes, anxiety, brain fog, digestive issues or fatigue, but standard medical tests keep coming back “normal”?

You’re not alone. These kinds of unexplained symptoms are more common than you might think, and in some cases, they may point to a condition many people don’t know much about: Mast Cell Activation Syndrome (MCAS).

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Neurodiversity: The Role of Genetics

Neurodiversity: The Role of Genetics

Neurodiversity is a concept that recognises and embraces the variety of ways the brain can function and process information. It celebrates neurological differences, such as autism, ADHD, dyslexia and other cognitive variations, as part of human diversity rather than viewing them as disorders. Genetic factors play a critical role in shaping the brain's development and function, and understanding the genetic basis of neurodiversity can offer valuable insights into individual strengths, challenges and potential interventions. This article explores key genes that influence neurological development and cognitive functions. Understanding these genes can empower individuals and their loved ones to make informed choices about their health, optimise brain function and explore personalised strategies for support in terms of nutrition, lifestyle and supplementation, which can quite literally be life changing for some individuals.

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Who is Gary Brecka and Why Should I do Methylation Testing?

Who is Gary Brecka and Why Should I do Methylation Testing?

Who Is Gary Brecka?

Gary Brecka is an American human biologist, biohacker, and longevity expert known for his cutting-edge work in functional and preventative health. With years of experience in the health and life insurance industry — where he specialised in mortality prediction— Gary Brecka now helps individuals take control of their health and prevent the development of disease.

He is the co-founder of 10X Health System, a wellness company offering blood analysis, genetic and methylation testing, and hormone optimisation. He is also the founder of The Ultimate Human, a platform designed to educate people about personalised health interventions that are rooted in their unique biology.

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The Benefits of Akkermansia for Gut Health

The Benefits of Akkermansia for Gut Health

Akkermansia is a species of bacteria found in the gut, particularly Akkermansia muciniphila, which is the most studied species. It is a gram negative (thin-walled) gut microbe that resides in the mucous layer (mucosa) of the gut lining (muciniphila meaning mucous loving) and directly interacts with intestinal cells which line the gut and form a crucial barrier.

Here are 6 potential benefits associated with Akkermansia:

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Empowering Your Fertility Journey with Functional Medicine and Nutrigenomics

Empowering Your Fertility Journey with Functional Medicine and Nutrigenomics

Embarking on a fertility journey can be both exciting and challenging, but taking control of your health can make a meaningful difference. Nutrition plays a key role—balancing hormones, supporting egg and sperm quality, and managing conditions like PCOS and endometriosis. Simple dietary changes, like increasing vitamin D and omega-3 intake, can positively impact reproductive health.

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Biohacking - 10 Benefits of Cryotherapy and Cold Therapy 

Biohacking - 10 Benefits of Cryotherapy and Cold Therapy 

Cryotherapy and cold therapy are gaining popularity in the biohacking world for their incredible health benefits. From reducing inflammation and speeding up muscle recovery to improving circulation and boosting mental resilience, cold exposure can transform your well-being. Explore the top 10 benefits of these cutting-edge therapies and how they can enhance your daily performance.

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Why Functional Testing? Seven Reasons It Can Transform Your Health

Why Functional Testing? Seven Reasons It Can Transform Your Health

Functional testing revolutionises health assessments by going beyond traditional methods to uncover underlying imbalances and deliver personalized health insights. This advanced approach empowers individuals to achieve optimal wellness through tailored recommendations, proactive prevention, and a comprehensive understanding of their unique biology.

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Understanding Seasonal Affective Disorder

Understanding Seasonal Affective Disorder

Seasonal Affective Disorder (SAD) is a form of depression that typically occurs in the darker months of fall and winter, triggered by reduced sunlight exposure. Common symptoms include persistent sadness, fatigue, and changes in sleep and appetite. Risk factors range from geographic location to pre-existing mental health conditions. Effective management includes light therapy, cognitive-behavioral therapy (CBT), medication, and dietary adjustments. Incorporating omega-3s, vitamin D, and regular outdoor exposure can also help. Explore how an integrated approach can alleviate SAD symptoms and support overall mental health.

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Folinic Acid vs. Methylfolate: Choosing the Right Form of Folate for Optimal Health

Folinic Acid vs. Methylfolate: Choosing the Right Form of Folate for Optimal Health

Folate is a vital nutrient for processes like DNA synthesis and neurotransmitter balance, especially through its role in the methylation cycle. For those with genetic variations impacting folate metabolism, choosing the right supplement form—folinic acid or methylfolate—can be essential to support optimal health. This article dives into the unique benefits of each form, explaining their roles in the body and providing guidelines on selecting the best option based on individual genetic needs and sensitivities.

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Methylation and Its Role in Health and Pregnancy

Methylation and Its Role in Health and Pregnancy

Methylation is a crucial biochemical process that influences numerous aspects of health, from regulating gene expression to detoxifying harmful substances. Impaired methylation can lead to conditions such as cardiovascular disease, mood disorders, hormonal imbalances, and pregnancy complications. Elevated homocysteine levels, due to common genetic polymorphisms like MTHFR, are associated with an increased risk of heart disease, stroke, and reproductive challenges. Fortunately, supplementing with methylated nutrients like 5-MTHF, methylcobalamin, and SAMe can help bypass these genetic inefficiencies, promoting better health outcomes, particularly during pregnancy and fertility.

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