A Guide To Methylation DNA Genetic Testing

A Guide To Methylation DNA Genetic Testing

Methylation DNA testing is very popular now thanks to world renowned biohackers like Gary Brecka from Ultimate Human and the UK’s own Tim Gray.

There are over 20,000 genes in the human body and with many labs offering methylation DNA testing it can be a daunting choice picking which one to order.

Here are some top tips from our Genetics Team to consider prior to purchasing;

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Longevity and Science-Backed Supplements

Longevity and Science-Backed Supplements

For biohackers focused on longevity, it’s all about targeting the underlying mechanisms of ageing. From mitochondrial health to reducing inflammation and clearing out senescent cells, supplement strategies can make a significant difference. Here’s a rundown of eight well-researched supplements that can help slow down the ageing process, each supported by scientific evidence. 

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Folinic Acid vs. Methylfolate: Choosing the Right Form of Folate

Folinic Acid vs. Methylfolate: Choosing the Right Form of Folate

Vitamin B9, commonly referred to as folate, comes in many forms, and choosing the right one can make a significant difference in how your body uses it. You’ve likely seen different names on food packaging or supplements, such as folic acid, folate, folinic acid, and 5-MTHF, but they’re not all created equal.

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How Genetics Affect Nutrient Absorption & Immunity

How Genetics Affect Nutrient Absorption & Immunity

The immune system is the body’s natural defense against infections, and its function can be influenced by many factors, including diet, genetics, and nutrient levels. While there is no single food or supplement that can provide a "magic boost" to the immune system, optimising nutrient intake is essential for supporting immune health. Nutrients like vitamins A, C, D, folate, iron, and zinc are key to maintaining strong immune responses, and genetic factors can influence how well your body absorbs and utilises these nutrients.

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COMT Gene: Worrier vs Warrior Explained

COMT Gene: Worrier vs Warrior Explained

Genetics play a significant role in shaping how we respond to stress, focus, and handle pressure, with the COMT (Catechol-O-methyltransferase) gene standing out as a key player in these areas. Known colloquially as the “Worrier Warrior” gene, COMT has variations that influence how our bodies process dopamine, a neurotransmitter vital for mood regulation, motivation, and cognitive performance.

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Best Supplements for ADHD Support (Evidence-Based Guide)

Best Supplements for ADHD Support (Evidence-Based Guide)

Whilst you can’t supplement your way out of any health condition, without considering diet, lifestyle and other factors such as genetics, gut health and toxin exposure, supplements can help improve cognitive function, such as focus and memory, reduce anxiety and support mood regulation in individuals with ADHD.

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Who is Gary Brecka and What is Methylation Testing?

Who is Gary Brecka and What is Methylation Testing?

Who Is Gary Brecka?

Gary Brecka is an American human biologist, biohacker, and longevity expert known for his cutting-edge work in functional and preventative health. With years of experience in the health and life insurance industry — where he specialised in mortality prediction— Gary Brecka now helps individuals take control of their health and prevent the development of disease.

He is the co-founder of 10X Health System, a wellness company offering blood analysis, genetic and methylation testing, and hormone optimisation. He is also the founder of The Ultimate Human, a platform designed to educate people about personalised health interventions that are rooted in their unique biology.

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Methylation and Its Role in Health and Pregnancy

Methylation and Its Role in Health and Pregnancy

Methylation is a crucial biochemical process that influences numerous aspects of health, from regulating gene expression to detoxifying harmful substances. Impaired methylation can lead to conditions such as cardiovascular disease, mood disorders, hormonal imbalances, and pregnancy complications. Elevated homocysteine levels, due to common genetic polymorphisms like MTHFR, are associated with an increased risk of heart disease, stroke, and reproductive challenges. Fortunately, supplementing with methylated nutrients like 5-MTHF, methylcobalamin, and SAMe can help bypass these genetic inefficiencies, promoting better health outcomes, particularly during pregnancy and fertility.

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Advice on Methylation DNA Testing

When you consume nutrients, you consume a lot of raw material that must be converted into a form the body can use. How does that raw material turn into hormones, neurons, and more? The process is called methylation.

Your DNA is set at birth and determines how your genes work. Methylation is the process which allows these genes to function optimally so understanding your personal methylation pathways is key to optimising your health. Methyl groups act like billions of switches which turn genes on or off, help regulate mood, detoxify hormones, produce energy, and promote healthy aging.

Since the process of methylation can be found throughout the entire body, it makes sense that poor methylation can cause issues. 

Here are some symptoms to watch out for if you suspect you may struggle with poor methylation:

  • Nervous system / mood issues

  • Gut dysbiosis

  • Trouble sleeping

  • Fatigue

  • Anxiety / Depression

  • Blood Pressure

  • Fertility

The Methylation Panel we offer can uncover needs for nutritional support such as amino acids, vitamins, and minerals. Knowing this can help guide dietary and lifestyle treatment plans. Additionally, knowing genetic predispositions can help focus supplementation to override potential methylation defects.

The methyl groups that participate in methylation come from a variety of micronutrients in your diet which include folate (B9), vitamin B12, vitamin B6, riboflavin (B2), betaine, choline, and several others. Knowing if you need these vitamins and minerals as supplements is key to managing good health.

The methylation DNA test is done via a simple cheek swab which is painless, quick and easy and your report is valid your whole life because genes do not change!

Having said that knowing your gene variants means you are forewarned and forearmed to deal with certain predispositions when it comes to other nutrients such as magnesium, zinc and glutathionine.

If you want to optimise your energy levels or cognitive function, or if you want to investigate mood or sleep challenges and detoxification pathways then this is the test for you.

Gary Brecka, world renowned Human Biologist says ‘We put raw materials into the human body, vitamins, amino acids, proteins and carbohydrates, but what if we cannot convert them into a usable form? This is called methylation. It is the most important process that every human goes through. If you have breaks in your methylation, you need to supplement for their deficiency because when you create a deficiency in the human body, it eventually leads to pathology and disease.”

Order your genetic methylation test HERE