Genetic variants this may be relevant for: SOD2; NOS3; CYP1B1; GSTP1; anyone with SNPs in their methylation genes (MTR; MTRR; MTHFR; COMT; AHCY) as suboptimal methylation can impact detoxification pathways and lead to raised homocysteine which can contribute to oxidative stress.

What is Oxidative Stress?

Oxidative stress occurs when there is an imbalance between free radicals (unstable molecules that can damage cells) and antioxidants (molecules that neutralise free radicals) in your body. Free radicals are produced naturally during metabolic processes but environmental factors like pollution, smoking and poor diet can increase their levels. Diminished antioxidant capacity and endogenous factors like high hormone load (stress and reproductive) can also contribute to oxidative stress.

How Does It Affect Your Health?

Cellular damage - excess free radicals can damage cell membranes, proteins and DNA, leading to cellular dysfunction and accelerated ageing.
Chronic disease - prolonged oxidative stress is linked to various health conditions, including cardiovascular disease, diabetes and certain cancers.
Inflammation - oxidative stress can exacerbate inflammatory responses, contributing to chronic inflammation and associated diseases.
Mental health - oxidative stress may affect brain function and is associated with mood imbalances and neurodegenerative conditions such as Alzheimer’s and Parkinson’s disease.

Symptoms of Oxidative Stress

Fatigue
Persistent inflammation
Poor wound healing
Unexplained muscle or joint pain
Premature ageing signs
Mood imbalances
Neurodegenerative conditions (e.g. Alzheimer’s, Parkinson’s)
Increased sensitivity or reactions due to elevated histamine (oxidative stress can damage cells and tissues, which may stimulate mast cells to release more histamine, leading to heightened allergic responses and inflammation. Additionally, chronic oxidative stress can impair the body's ability to metabolise and clear histamine, further exacerbating symptoms).

How to Manage Oxidative Stress

Increase antioxidant intake - consume foods rich in antioxidants like fruits, vegetables, nuts and seeds. Key antioxidants include vitamins C and E, selenium and flavonoids.
Limit exposure to toxins - reduce your intake of alcohol, avoid smoking and minimise exposure to environmental pollutants. Switch to natural cleaning and beauty products, you can browse our range here https://mybodyfab.co.uk/collections/wellness-products
Stay active - engage in regular, moderate exercise which can boost your body’s antioxidant defences and support detoxification pathways.
Manage stress - practise stress-relief techniques such as mindfulness, meditation and breathing exercises to help reduce oxidative stress.
Avoid excessive sun exposure - protect your skin from harmful UV rays that can increase free radical production.

Supplements to Support Oxidative Stress Management

Vitamin C - a potent antioxidant that helps protect cells from free radical damage and supports immune function - BUY HERE
Selenium - a trace mineral that helps the body produce antioxidant enzymes, supporting overall antioxidant defence - BUY HERE
Coenzyme Q10 (CoQ10) - an antioxidant that supports cellular energy production and protects cells from oxidative damage - BUY HERE
N-Acetyl Cysteine (NAC) - supports the production of glutathione, a major antioxidant in the body, and helps detoxify free radicals - BUY HERE
Glutathione - one of the body’s master antioxidants that helps neutralise free radicals, supports detoxification processes and maintains cellular health - BUY HERE

Please consult your health plan for your supplement recommendations or speak with our team to see if any of the supplements would be beneficial for you - BOOK ADVICE CALL HERE

Understanding and managing oxidative stress is crucial for optimising methylation, maintaining overall health and reducing chronic disease risk. By adopting a nutrient-dense, antioxidant rich diet, limiting toxin exposure and managing stress, you can help protect your body from the effects of oxidative damage and support your long-term well-being.